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Dr Jody Mason has been awarded an Alzheimer’s Research UK Major Project Grant to look for small compounds called peptides which might be able to prevent the build-up of toxic proteins in the brain linked to Parkinson’s disease and related dementias.
Dr Mason, from the Department of Biology & Biochemistry, has been awarded £332,000 over three years to identify peptides which can halt the build-up of so-called Lewy bodies. These are toxic clumps of proteins within dopamine-producing cells, which interfere with normal brain function.
The research team, working alongside Dr Rob Williams’ group, will sift through vast mixtures of peptides, short chains of amino acids, within living cells. This will identify which stop Lewy bodies from forming by sticking to a key protein and most importantly detoxifying it.
By characterising the function of any promising peptides, and testing them inside brain cells for safety and efficacy, the team hope to eventually identify peptides which could become new therapeutic drugs. The award is highly interdisciplinary, involving collaborators at the University of Queensland in Australia with considerable expertise towards turning peptide-based compounds into drugs.
Dr Mason said: “We are very grateful for Alzheimer’s Research UK recognising our work and for funding the project. Toxic neuronal inclusions known as Lewy bodies are key causative agents in Parkinson’s disease pathology. We will now study how cell death and clumping are linked and therefore how toxicity can be prevented using our cell-derived peptides, offering the possibility to develop pre-clinical drug leads or diagnostics towards a Parkinson’s treatment.”
Dr Rob Williams added: “There is an urgent need for treatments to halt the progression of Parkinson’s disease and Dementia with Lewy Bodies and these peptides offer a new therapeutic approach to tackle the problem.”
Dr Sara Imarisio, Head of Research at Alzheimer’s Research UK said: “There are 850,000 people living with dementia in the UK, including 87,000 people in the South West, and as we are all living longer, this number is set to rise. While age is a big risk factor for dementia, it is not a normal part of ageing. Dementia is the result of physical changes to the brain caused by diseases like Alzheimer’s. Understanding the complex process that contribute to the development of Alzheimer’s disease is crucial in the hunt for new treatments.
“We are delighted to support pioneering research projects in Bath. Alzheimer’s Research UK receives no government funding for the research we support and it is only thanks to the generosity of our supporters that we’re able to fund vital dementia research.”
The research grant will support a postdoctoral researcher in Dr Mason’s group and Research Technician in Dr William’s group for the duration of the study. Dr Mason’s lab is also investigating how peptides might be used to combat certain kinds of cancers.

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Recent advancements in technology are changing the way we interact with our home and the appliances we own. Technology helps us increase efficiency in our everyday lives. It also has many other benefits that will make our lives easier. Many people might not know what smart appliances can do, especially those who currently own the older generation products. When you are ready to replace your appliances, here are some of the benefits that can improve your kitchen, your cooking. and your appliance safety.
In the past, problems with your appliances may have occurred unnoticed until the issue either became bigger, unfixable, or even more dangerous. Receiving alerts to a problem when an appliance detects a tiny mis-performance can greatly improve safety and performance. With most household appliances, the sooner you notice a problem the better. Many appliance issues aren’t noticed until they became a visible issue. It can be something as big as a gas leak or something small like the refrigerator door was left open. Maybe you closed the oven but forgot to turn it off before heading out for a trip. You can now receive messages and turn off appliances remotely with your phone. Remote diagnostics will notify you about these problems right away when they detect them, and the issue can be resolved sooner rather than later, providing safety and savings in both electricity costs and maintenance.
All smart appliances can be connected using their mobile applications and controlled through their apps. This can range from controlling your oven’s temperature while you briefly step out of the house or while watching a movie and turning it on or off remotely in case you forgot. You can even brew a morning cup of coffee the way you wanted every morning from the coffee machine.
Smart Refrigerators allow you to control the temperature and humidity settings. Some even take a picture whenever you close your refrigerator door allowing the image of what’s inside to appear on the door. You can see what is currently in your refrigerator while at the supermarket or before you decide to open your fridge (saving energy). These are very helpful ways to use smart appliances with your phone to control your kitchen and make life easier..
Other smart appliances can also be connected to Amazon Dash Replenishment service, making restocking orders happen seamlessly. To find out more about automatic replenishment service read about it here.
A smart refrigerator can recommend dishes to cook based on what is inside, saving you from indecisiveness and prevent food from going bad. The oven has been modified to improve your kitchen experience as well. With the new smart oven, simply place food in the oven to bake, then set it, and forget it. There is no need to be present when the dish is ready to come out. Once the desired bake time has been achieved, the oven goes into warming mode and keeps the food hot until it is ready to serve. Talk about making your life easier with technology! Applications like Drop Recipes allows you to make the food you love by following a guided cooking process with helpful tips and detailed steps. If you use their drop scale, you can easily mix an exact measurements of ingredients.
While some technologies are only in early development, the future is already here. Some elements of a smart home may require significant investment and getting used to. Others are simple, affordable, and can impact your home right now. Making small changes to your home’s kitchen functionality can help you improve the quality of your life, saving you a piece of mind. Be sure to talk with your designer about these options. Call or email today for an appointment. 516-746-3435.
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world map decor you searched for world map decor etsy is the home to thousands of handmade vintage and one of a kind products and ts to your search no matter what you’re looking for or where you are in the world our global marketplace of sellers can help you find unique and affordable options let’s started amazon world map wall decor kreative arts 3 pieces canvas prints wall art travel world map poster vintage wood style modern wall decor stretched gallery canvas wrap giclee print ready to hang 20x36inchx3pcs wood style map world map wall art wayfair shop wayfair for all the best world map wall art enjoy free shipping on most stuff even big stuff world map decor bedroom amazon my husband and i ordered this world map decal for our baby nook and we have not plaints the pieces were easy to peel and transfer to the wall even if you made a mistake and had to reapply diy wanderlust room decor i always have a desire to travel the world even tho i m scared of planes yeah long story and making these decor pieces i have a feeling like i m instantly in some other country call it weird
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A major review of over 400 research articles studying the association between acts of terrorism and mental health has reached the significant conclusion that ‘terrorism isn’t terrorising’ – at least not in a way that causes increases in post-traumatic stress disorder (PTSD) greater than would be expected from any other distressing event.
The findings, released today [Wednesday 17 October] in The Lancet Psychiatry from researchers at the University, run counter to much commentary on the topic, which usually suggests that an increase in terrorist attacks will have a negative impact on peoples’ psychological wellbeing. Such an association, say the researchers, is overstated due to a modern day tendency to imagine the worst, particularly on matters relating to mental health.
By conducting an extensive review and analysis of the research published both pre and post 9/11, the team involved note that attempts to understand the links between terrorism and mental health are actually quite recent. In fact, there was almost no such focus until shortly before 9/11 following which there was a spike in articles focused on the assumed connection. The study highlights that this was encouraged by the recognition of post-traumatic stress disorder (PTSD) and its redefinition by the American Psychological Association in 1994 in a cultural climate also more attuned to emotional hurt. Most of the articles analysed for this study were published post 9/11.
Yet, in spite of increasing attention to the subject, the researchers found no clear association between terror events and cases of PTSD in the literature. Their findings suggest that many studies were drawn to expanding what was meant by the term, allowing categories such as ‘pre-PTSD’ or ‘PTSD-symptom’ to be audited instead.
This, they argue, confuses and conflates what is meant by PTSD and has the negative effect of ignoring other significant impacts tied to terror events – not least social, economic and physical ones. They also suggest that expanding what constitutes PTSD may lead to the minority who genuinely suffer from its effects being less able to access the support they really need.
Instead, they suggest that policy-makers would do better to note how people usually cope by making use of their own networks and initiative, and to encourage responses to terrorist events that highlight social bonds and people’s resilience, rather than their psychological vulnerability.
Lead author, Professor Bill Durodie from the Department of Politics, Languages & International Studies explained: “After 9/11 there was an enormous push to uncover evidence of PTSD in people who said that they had been affected by those events either directly or indirectly through the media.
“Despite this, the reassuring conclusion of our work is that terrorism does not terrorise – at least not any more than being traumatised by any other challenging event. In that regard, our findings fly in the face of various announcements from politicians, officials, the media and even other academics that terrorist incidents impact our mental health and wellbeing adversely.
“This is not to say that people who experience traumatic events do not need psychological support, but we believe that it is unhelpful to categorise more people than is true with PTSD. We are also saying that there were many other effects of 9/11 that were overlooked – primarily respiratory disorders, as well as economic and social ones, such as people losing their jobs.
“There is clear evidence of people’s resilience in the face of such events and so, for us, it is important for politicians, the media and commentators to take these findings on board and re-focus attention more on this in the face of such terrible events.”
Dr David Wainwright, Senior Lecturer in the University’s Department for Health, added: “Notably, our work also drew into question the presumption that people, particularly the young, can be traumatised merely through watching such events unfold on TV. Some researchers did rush to such conclusions but usually retracted them a few years later. Unfortunately though, it is their earlier, impressionistic assumptions that continue to be cited in many instances, despite most noting that there is no conclusive evidence on this.
“Of course, young people should be protected from events and have these explained to them. They may need to have their television viewing limited too. But this has more to do with the challenges of asserting parental authority today – a social factor - than media or medical effects that are deemed to be inevitable. The inordinate focus on children in the work we reviewed may also express an unstated desire to control adult responses through the auspices of protection.”
Professor Durodie acknowledges the support of the Gerda Henkel Stiftung in Germany for their provision of funds under their Special Programme for Security, Society and the State that has assisted this work.

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Choose the Best White Bathroom Mirror, Just like the method that you may wish to pick and choose accessories and further fittings in your bedroom, I am convinced you may wish to in your bathroom at the same time. Bathroom accessories and fittings are becoming very popular among people now you will find there's great demand for customized and stylish looking bath fittings and accessories. Just as the method that you would really like a say inside look of the bedroom and drawing room, you need to certainly have a very say on what your bathrooms really should look. It also adds to the overall fun quotient of designing your house to match on the best of what you need.
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The last two weeks my oldest has been late to school at least once. It’s a big event for her because she hates being late, but then she’s slow as molasses (like most kids) when it comes to getting ready.
Today’s video is about how I let her have a problem because this is the best time to not bail her out and let her solve her own problems.
Also, make note of the books I talk about, how are you challenging your parenting assumptions?

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Research Associate - Fixed Term Contract
This post is to generate synthetic average and extreme current and future weather files covering the entire land surface of this country. These will then be used to investigate building designs produced by other team members. A preliminary method for the generation of average weather files using data from the UK Met Office has been devised, but will require further work to assimilate multi-ensemble data using probabilistic methods. The core task will however involve the definition and creation of an extreme weather file type for India using the UKMO data, and their subsequent production. In addition, the post holder will create an online portal to provide these files on-demand using the high-performance computing (HPC) facility at Bath.
The successful candidate will have a first degree and doctorate in science, mathematics or engineering, have good knowledge of computer programming. Knowledge of statistical and mathematical analysis techniques and database creation and maintenance will be highly advantageous, as would above average paper output for their career stage. In addition to the core scientific tasks listed above, the applicant will also be required to support work on other aspects of the project, as directed by the investigators, and undertake a series of impact related activities, which may require periodic travel outside the UK. We are therefore looking for enthusiastic and committed individuals with strong people skills to work in a multi-disciplinary team consisting of building physicists, architects, computer scientists, weather scientists, psychologists and others.
You will join the EDEn (Energy and Design of Environments) research group within the Department of Architecture and Civil Engineering, but work closely with other co-investigators, including those in the developing country. For more information on EDEn, see http://www.bath.ac.uk/ace/eden.
This post is full-time basis (36.5hrs per week) and is being offered on a fixed term contract basis with an anticipated expiry date of 30 November 2020.
For an informal discussion about the position please contact Dr Sukumar Natarajan ([email protected]) or Prof. David Coley ([email protected])
